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Anti-ATP2C1 Polyclonal Antibody (PTX20045)

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概述
货号PTX20045
品牌ProteoGenix
描述
Anti-ATP2C1 Polyclonal Antibody (PTX20045) is a rabbit polyclonal antibody detecting Calcium-transporting ATPase type 2C member 1, ATP-dependent Ca(2+) pump PMR1, PMR1L, KIAA1347, ATP2C1, ATPase 2C1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human ATP2C1 (Val313-Ile699).
靶标Calcium-transporting ATPase type 2C member 1, ATP-dependent Ca(2+) pump PMR1, PMR1L, KIAA1347, ATP2C1, ATPase 2C1
纯化方式Purified by antigen affinity column.
Accession号P98194
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Calcium-transporting ATPase type 2C member 1 (ATP2C1) is a ~100 kDa protein. ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology. Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity.

1. Fairclough, RJ. et al. (2003) The Journal of biological chemistry 278, 24721-30. PMID: 12707275
2. Dode, L. et al. (2005) The Journal of biological chemistry 280, 39124-34. PMID: 16192278
3. Lissandron, V. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 9198-203. PMID: 20439740
4. Mukhopadhyay, S. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 858-63. PMID: 21187401
5. Chen, J. et al. (2019) The Journal of biological chemistry 294, 7878-7891. PMID: 30923126
6. Dode, L. et al. (2006) The Journal of biological chemistry 281, 3182-9. PMID: 16332677
7. Behne, MJ. et al. (2003) The Journal of investigative dermatology 121, 688-94. PMID: 14632183
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-ATP2C1 Polyclonal Antibody

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