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Anti-ORF8/ns8 Polyclonal Antibody (PTXCOV-A560)

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概述
货号PTXCOV-A560
品牌ProteoGenix
描述
Anti-ORF8/ns8 Polyclonal Antibody (PTXCOV-A560) is a rabbit polyclonal antibody detecting ORF8 protein,ORF8,Non-structural protein 8,ns8 in ELISA, IHC, WB. Suitable for SARS-CoV-2 (2019-nCoV).
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性SARS-CoV-2 (2019-nCoV)
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant SARS-CoV-2 ORF8/ns8 (Phe16-Ile121).
靶标ORF8 protein,ORF8,Non-structural protein 8,ns8
纯化方式Purified by antigen affinity column.
Accession号P0DTC8
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

ORF8 protein (ns8) is a ~13 kDa protein. Plays a role in modulating the host immune response. May act as a secreted virokine by mimicking interleukin-17A (IL17A), and thereby binding to the IL17RA receptor, leading to activation of the IL17 pathway and increased secretion of pro-inflammatory factors. Contributes to the cytokine storm during SARS-CoV-2 infection when secreted by unconventional pathway. May act by down-regulating major histocompability complex class I (MHC-I) at cell surface. May inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58.

1. Chan, JF. et al. (2020) Lancet (London, England) 395, 514-523. PMID: 31986261
2. Wu, X. et al. (2022) mBio 13, e0040222. PMID: 35343786
3. Lin, X. et al. (2023) PLoS pathogens 19, e1011128. PMID: 36689483
4. Lin, X. et al. (2021) iScience 24, 102293. PMID: 33723527
5. Zhang, Y. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34021074
6. Matsuoka, K. et al. (2022) The Journal of biological chemistry 298, 101724. PMID: 35157849
7. Geng, H. et al. (2021) Frontiers in immunology 12, 679482. PMID: 34177923
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-ORF8/ns8 Polyclonal Antibody

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