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Anti-Mouse GPC3 Antibody (7C8) (PTX19179)

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概述
货号PTX19179
品牌ProteoGenix
描述
Anti-Mouse GPC3 Antibody (7C8) [7C8] (PTX19179) is a rat monoclonal antibody detecting GPC3, MXR7, GTR2-2, Glypican-3, Intestinal protein OCI-5, OCI5 in Blocking, ELISA, FCM. Suitable for Mouse.
Highlights
  • Protein A/G purified from cell culture supernatant. — Ensuring high specificity and minimal background.
  • Multi-Application — Validated across multiple applications.
种属反应性Mouse
应用Blocking, ELISA, FCM
宿主Rat
同种型IgG1
克隆号7C8
克隆类型Monoclonal
靶标GPC3, MXR7, GTR2-2, Glypican-3, Intestinal protein OCI-5, OCI5
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q8CFZ4
状态Liquid
保存溶液 0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景

Glypican-3 (GPC3/Glypican 3) is a ~65 kDa protein. Cell surface proteoglycan. Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins. Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation. Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands. Positively regulates the non-canonical Wnt signaling pathway.

1. Capurro, MI. et al. (2008) Developmental cell 14, 700-11. PMID: 18477453
2. Bhave, VS. et al. (2013) The American journal of pathology 183, 153-9. PMID: 23665349
3. Song, HH. et al. (2005) The Journal of biological chemistry 280, 2116-25. PMID: 15537637
4. Paine-Saunders, S. et al. (2000) Developmental biology 225, 179-87. PMID: 10964473
5. Grisaru, S. et al. (2001) Developmental biology 231, 31-46. PMID: 11180950
6. Ng, A. et al. (2009) Developmental biology 335, 208-15. PMID: 19733558
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Mouse GPC3 Antibody (7C8)

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