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Anti-Mouse IFNG/IFN-gamma Antibody (XMG1.2) (PTX19189)

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概述
货号PTX19189
品牌ProteoGenix
描述
Anti-Mouse IFNG/IFN-gamma Antibody (XMG1.2) [XMG1.2] (PTX19189) is a rat monoclonal antibody detecting Interferon gamma, IFN-gamma, Immune interferon, IFNG in FCM. Suitable for Mouse.
Highlights
  • Protein A/G purified from cell culture supernatant. — Ensuring high specificity and minimal background.
  • Validated for FCM — Optimized for consistent performance.
种属反应性Mouse
应用FCM
宿主Rat
克隆类型Monoclonal
同种型IgG1, kappa
克隆号XMG1.2
靶标Interferon gamma, IFN-gamma, Immune interferon, IFNG
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P01580
状态Liquid
保存溶液 0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景

Interferon gamma (IFNG/IFN-gamma) is a ~17 kDa protein. Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.

1. Pearl, JE. et al. (2001) Cellular immunology 211, 43-50. PMID: 11585387
2. Huang, S. et al. (1993) Science (New York, N.Y.) 259, 1742-5. PMID: 8456301
3. Baldridge, MT. et al. (2010) Nature 465, 793-7. PMID: 20535209
4. Matatall, KA. et al. (2014) Stem cells (Dayton, Ohio) 32, 3023-30. PMID: 25078851
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Mouse IFNG/IFN-gamma Antibody (XMG1.2)

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