Protein A/G purified from cell culture supernatant.
Accession号
P17643
状态
Liquid
保存溶液
0.01M PBS, pH 7.4.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景
5,6-dihydroxyindole-2-carboxylic acid oxidase (TYRP1) is a ~60 kDa protein. Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.
1. Rooryck, C. et al. (2006) Pigment cell research 19, 239-42. PMID: 16704458
2. Kenny, EE. et al. (2012) Science (New York, N.Y.) 336, 554. PMID: 22556244
3. Simeonov, DR. et al. (2013) Human mutation 34, 827-35. PMID: 23504663
4. Lai, X. et al. (2017) Angewandte Chemie (International ed. in English) 56, 9812-9815. PMID: 28661582
