Nuclear protein 1 (NUPR1) is a ~8 kDa protein. Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses. Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A. Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation. Negatively regulates apoptosis through interaction with PTMA. 1. Encinar, JA. et al. (2001) The Journal of biological chemistry 276, 2742-51. PMID: 110561692. Hoffmeister, A. et al. (2002) The Journal of biological chemistry 277, 22314-9. PMID: 119405913. Malicet, C. et al. (2006) Biochemical and biophysical research communications 339, 284-9. PMID: 163007404. Malicet, C. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 2671-6. PMID: 164788045. Clark, DW. et al. (2008) Current cancer drug targets 8, 421-30. PMID: 186908486. Gironella, M. et al. (2009) Journal of cellular physiology 221, 594-602. PMID: 196500747. Sambasivan, R. et al. (2009) Journal of cell science 122, 3481-91. PMID: 197238048. Kong, DK. et al. (2010) Molecular biology of the cell 21, 1335-49. PMID: 201818289. Hamidi, T. et al. (2012) The Journal of clinical investigation 122, 2092-103. PMID: 2256531010. Vincent, AJ. et al. (2012) FEBS letters 586, 3429-34. PMID: 22858377 | 
