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Anti-Human CFTR Monoclonal Antibody (1A509) (HY313025)

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概述
货号HY313025
品牌abinScience
描述
Anti-Human CFTR Monoclonal Antibody (1A509) [1A509] (HY313025) is a mouse monoclonal antibody detecting CFTR in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
  • ●Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Mouse
克隆类型Monoclonal
同种型IgG
克隆号1A509
免疫原E. coli - derived recombinant human CFTR (Ile1203-Ser1426).
靶标Cystic fibrosis transmembrane conductance regulator, CFTR, ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, EC:5.6.1.6, cAMP-dependent chloride channel, CFTR
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P13569
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Cystic fibrosis transmembrane conductance regulator (CFTR) is a ~168 kDa protein. Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. In vitro, mediates ATP-dependent glutathione flux.

1. Shah, VS. et al. (2016) Science (New York, N.Y.) 351, 503-7. PMID: 26823428
2. Ostedgaard, LS. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5657-62. PMID: 10792060
3. Ramjeesingh, M. et al. (2001) Biochemistry 40, 10700-6. PMID: 11524016
4. Cheng, J. et al. (2002) The Journal of biological chemistry 277, 3520-9. PMID: 11707463
5. Hallows, KR. et al. (2003) American journal of physiology. Cell physiology 284, C1297-308. PMID: 12519745
6. Silvis, MR. et al. (2003) The Journal of biological chemistry 278, 11554-60. PMID: 12529365
7. Chappe, V. et al. (2003) The Journal of physiology 548, 39-52. PMID: 12588899
8. Kogan, I. et al. (2003) The EMBO journal 22, 1981-9. PMID: 12727866
9. Shcheynikov, N. et al. (2004) The Journal of biological chemistry 279, 21857-65. PMID: 15010471
10. Mense, M. et al. (2006) The EMBO journal 25, 4728-39. PMID: 17036051
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for Anti-Human CFTR Monoclonal Antibody (1A509)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human CFTR Monoclonal Antibody (1A509)

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