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Anti-Human FUT4 Monoclonal Antibody (1A563) (HB132015)

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概述
货号HB132015
品牌abinScience
描述
Anti-Human FUT4 Monoclonal Antibody (1A563) [1A563] (HB132015) is a mouse monoclonal antibody detecting FUT4 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
  • ●Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Mouse
克隆类型Monoclonal
同种型IgG
克隆号1A563
免疫原E. coli - derived recombinant human FUT4 (Asp264-Thr497).
靶标Alpha-(13)-fucosyltransferase 4, 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, EC:2.4.1.152, ELAM-1 ligand fucosyltransferase, Fucosyltransferase 4, Fucosyltransferase IV, Fuc-TIV, FucT-IV, Galactoside 3-L-fucosyltransferase, FUT4
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P22083
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Alpha-(1,3)-fucosyltransferase 4 (FUT4) is a ~59 kDa protein. Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE.

1. Goelz, SE. et al. (1990) Cell 63, 1349-56. PMID: 1702034
2. Lowe, JB. et al. (1991) The Journal of biological chemistry 266, 17467-77. PMID: 1716630
3. Mondal, N. et al. (2018) The Journal of biological chemistry 293, 7300-7314. PMID: 29593094
4. Nakayama, F. et al. (2001) The Journal of biological chemistry 276, 16100-6. PMID: 11278338
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for Anti-Human FUT4 Monoclonal Antibody (1A563)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human FUT4 Monoclonal Antibody (1A563)

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