| 货号 | HB132016 |
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| 品牌 | abinScience |
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| 种属反应性 | Human |
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| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| 宿主 | Mouse |
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| 同种型 | IgG2a, kappa |
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| 生物活性 | Fanolesomab uses a technetium-99m label, enables white blood cell labeling, eliminates need for handling blood products, and is readily available. Fanolesomab exhibits 100% specificity in infection imaging [1]. |
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| 表达系统 | Mammalian cells |
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| 克隆类型 | Monoclonal |
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| 靶标 | Alpha-(1, 3)-fucosyltransferase 4, ELAM-1 ligand fucosyltransferase, Fucosyltransferase 4, Fucosyltransferase IV, Galactoside 3-L-fucosyltransferase, Fuc-TIV, FCT3A, FUT4, ELFT, FucT-IV |
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| 内毒素水平 | < 10 EU/mg |
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| 纯度 | >95% purity as determined by SDS-PAGE. |
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| 纯化方式 | Protein A/G purified from cell culture supernatant. |
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| Accession号 | P22083 |
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| 状态 | Liquid |
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| 保存溶液 |
0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
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| 别名 | Fanolesomab |
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| 背景 | Alpha-(1,3)-fucosyltransferase 4 (CD15/SSEA-1) is a ~59 kDa protein. Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE. 2. Lowe, JB. et al. (1991) The Journal of biological chemistry 266, 17467-77. PMID: 17166303. Mondal, N. et al. (2018) The Journal of biological chemistry 293, 7300-7314. PMID: 295930944. Nakayama, F. et al. (2001) The Journal of biological chemistry 276, 16100-6. PMID: 11278338 |
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| 文献 | 1. Klingensmith WC 3rd, et al. Intrapatient comparison of 2-deoxy-2-[F-18]fluoro-D-glucose with positron emissiontomography/computed tomography to Tc-99m fanolesomab (NeutroSpec) for localization of infection. Mol Imaging Biol. 2007;9(5):295-299. [HB132016] |
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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