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Anti-Human CD21/CR2 Monoclonal Antibody (1A617) (HB939035)

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概述
货号HB939035
品牌abinScience
描述
Anti-Human CD21/CR2 Monoclonal Antibody (1A617) [1A617] (HB939035) is a mouse monoclonal antibody detecting CD21 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
  • ●Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Mouse
克隆类型Monoclonal
同种型IgG
克隆号1A617
免疫原E. coli - derived recombinant human CD21/CR2 (Lys729-Asp958).
靶标Complement receptor type 2, Cr2, Complement C3d receptor, Epstein-Barr virus receptor, EBV receptor, CD21, CR2
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P20023
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Complement receptor type 2 (CD21/CR2) is a ~112 kDa protein. Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner.

1. Delcayre, AX. et al. (1991) The EMBO journal 10, 919-26. PMID: 1849076
2. van den Elsen, JM. et al. (2011) Science (New York, N.Y.) 332, 608-11. PMID: 21527715
3. Barel, M. et al. (1995) Molecular immunology 32, 389-97. PMID: 7753047
4. Bradbury, LE. et al. (1992) Journal of immunology (Baltimore, Md. : 1950) 149, 2841-50. PMID: 1383329
5. Franco, A. et al. (2018) International immunology 30, 569-578. PMID: 30107486
6. Barel, M. et al. (2003) European journal of immunology 33, 2557-66. PMID: 12938232
7. Aubry, JP. et al. (1992) Nature 358, 505-7. PMID: 1386409
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for Anti-Human CD21/CR2 Monoclonal Antibody (1A617)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human CD21/CR2 Monoclonal Antibody (1A617)

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