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Anti-Human SLC6A4 Monoclonal Antibody (1A665) (HB725015)

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概述
货号HB725015
品牌abinScience
描述
Anti-Human SLC6A4 Monoclonal Antibody (1A665) [1A665] (HB725015) is a mouse monoclonal antibody detecting SLC6A4 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
  • ●Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Mouse
同种型IgG
克隆号1A665
克隆类型Monoclonal
免疫原E. coli - derived recombinant human SLC6A4 (Ala181-Ser252).
靶标Sodium-dependent serotonin transporter, SERT, 5HT transporter, 5HTT, Solute carrier family 6 member 4, SLC6A4
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P31645
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Sodium-dependent serotonin transporter (SLC6A4) is a ~70 kDa protein. Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling. Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse.

1. Mortensen, OV. et al. (1999) Brain research. Molecular brain research 71, 120-6. PMID: 10407194
2. Kilic, F. et al. (2003) Molecular pharmacology 64, 440-6. PMID: 12869649
3. Henry, LK. et al. (2011) The Journal of biological chemistry 286, 30823-30836. PMID: 21730057
4. Coleman, JA. et al. (2016) Nature 532, 334-9. PMID: 27049939
5. Hasenhuetl, PS. et al. (2016) The Journal of biological chemistry 291, 25864-25876. PMID: 27756841
6. Yang, D. et al. (2021) Science advances 7, eabl3857. PMID: 34851672
7. Brenner, B. et al. (2007) Journal of neurochemistry 102, 206-15. PMID: 17506858
8. Carneiro, AM. et al. (2008) The Journal of clinical investigation 118, 1544-52. PMID: 18317590
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for Anti-Human SLC6A4 Monoclonal Antibody (1A665)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human SLC6A4 Monoclonal Antibody (1A665)

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