Recombinant Human SLC6A4 Protein, N-GST (PX-P5927)
概述
图片
参考文献
概述
货号
PX-P5927
品牌
ProteoGenix
描述
Recombinant Human SLC6A4 Protein, N-GST (PX-P5927) expressed in E. coli, Purity: >90% as determined by SDS-PAGE..
Highlights
High Purity (>90% as determined by SDS-PAGE.) — Verified by SDS-PAGE for downstream accuracy.
E. coli Expression — Optimized for functional studies.
表达系统
E. coli
Accession号
P31645
蛋白长度
Ala181-Ser252
应用
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属
Homo sapiens (Human)
性质
Recombinant
内毒素水平
Please contact with the lab for this information.
纯度
>90% as determined by SDS-PAGE.
预测分子量
35.14 kDa
状态
Lyophilized
保存溶液
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名
5HT transporter, 5HTT, SERT, Sodium-dependent serotonin transporter, Solute carrier family 6 member 4, HTT, SLC6A4
背景
Sodium-dependent serotonin transporter (SLC6A4/SERT) is a ~70 kDa protein. Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling. Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse.
1. Mortensen, OV. et al. (1999) Brain research. Molecular brain research 71, 120-6. PMID: 10407194
2. Kilic, F. et al. (2003) Molecular pharmacology 64, 440-6. PMID: 12869649
3. Henry, LK. et al. (2011) The Journal of biological chemistry 286, 30823-30836. PMID: 21730057
