Anti-Mouse IFN-gamma Polyclonal Antibody (MF813014)

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概述
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参考文献
产品说明书

概述

货号

MF813014

品牌

abinScience

描述

Anti-Mouse IFNG/IFN-gamma Polyclonal Antibody (MF813014) is a rabbit polyclonal antibody detecting IFN-gamma in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant mouse IFNG/IFN-gamma (His23-Cys155).

靶标

IFN-gamma, Ifng, Interferon gamma

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P01580

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Interferon gamma is a ~17 kDa protein. Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.

1. Pearl, JE. et al. (2001) Cellular immunology 211, 43-50. PMID: 11585387

2. Huang, S. et al. (1993) Science (New York, N.Y.) 259, 1742-5. PMID: 8456301

3. Baldridge, MT. et al. (2010) Nature 465, 793-7. PMID: 20535209

4. Matatall, KA. et al. (2014) Stem cells (Dayton, Ohio) 32, 3023-30. PMID: 25078851

Note

For research use only

图片

参考文献

产品说明书

Anti-Mouse IFN-gamma Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse IFN-gamma Polyclonal Antibody (MF813014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse IFN-gamma Polyclonal Antibody (MF813014)

概述

图片

参考文献

产品说明书

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