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Anti-BECN1 Polyclonal Antibody (ARO-A12749)

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概述
货号ARO-A12749
品牌ProteoGenix
描述
Anti-BECN1 Polyclonal Antibody (ARO-A12749) is a rabbit polyclonal antibody detecting BECN1, Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, GT197 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human BECN1 (Thr141-Lys450).
靶标BECN1, Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, GT197
纯化方式Purified by antigen affinity column.
Accession号Q14457
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Beclin-1 (BECN1) is a ~51 kDa protein. Plays a central role in autophagy. Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis.

1. Wei, Y. et al. (2008) Molecular cell 30, 678-88. PMID: 18570871
2. Strappazzon, F. et al. (2011) The EMBO journal 30, 1195-208. PMID: 21358617
3. Margariti, A. et al. (2013) The Journal of biological chemistry 288, 859-72. PMID: 23184933
4. Xia, P. et al. (2013) The EMBO journal 32, 2685-96. PMID: 23974797
5. Xu, C. et al. (2014) Autophagy 10, 2239-50. PMID: 25484083
6. Ashkenazi, A. et al. (2017) Nature 545, 108-111. PMID: 28445460
7. Wyatt, S. et al. (2023) Biochemistry 62, 2934-2951. PMID: 37776275
8. Sagona, AP. et al. (2010) Nature cell biology 12, 362-71. PMID: 20208530
9. Thoresen, SB. et al. (2010) Experimental cell research 316, 3368-78. PMID: 20643123
10. Liu, K. et al. (2016) The Journal of cell biology 212, 181-98. PMID: 26783301
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-BECN1 Polyclonal Antibody

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