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Anti-Mouse ROBO3 Polyclonal Antibody (ARO-A12781)

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概述
货号ARO-A12781
品牌ProteoGenix
描述
Anti-Mouse ROBO3 Polyclonal Antibody (ARO-A12781) is a rabbit polyclonal antibody detecting Roundabout-like protein 3, ROBO3, Roundabout homolog 3 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Mouse
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Mouse ROBO3 (Gly173-Val345).
靶标Roundabout-like protein 3, ROBO3, Roundabout homolog 3
纯化方式Purified by antigen affinity column.
Accession号Q9Z2I4
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Roundabout homolog 3 (ROBO3) is a ~149 kDa protein. Receptor involved in axon guidance during development. Acts as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits SLIT repulsion, and facilitates Netrin-1/NTN1 attraction. In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1/ROBO2. Binding OF NELL2 to the receptor ROBO3 promotes oligomerization of ROBO3, resulting in the repulsion of commissural axons in the midline. ROBO3 also indirectly boosts axon attraction to NTN1 without interacting with NTN1 itself.

1. Sabatier, C. et al. (2004) Cell 117, 157-69. PMID: 15084255
2. Chen, Z. et al. (2008) Neuron 58, 325-32. PMID: 18466743
3. Zelina, P. et al. (2014) Neuron 84, 1258-72. PMID: 25433640
4. Zhuang, M. et al. (2019) Nucleic acids research 47, 4765-4777. PMID: 30843071
5. Pak, JS. et al. (2020) Nature communications 11, 1489. PMID: 32198364
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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