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Anti-Human RUBCN Polyclonal Antibody (ARO-A12954)

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概述
货号ARO-A12954
品牌ProteoGenix
描述
Anti-Human RUBCN Polyclonal Antibody (ARO-A12954) is a rabbit polyclonal antibody detecting RUBCN, KIAA0226, Beclin-1 associated RUN domain containing protein, Rubicon, Baron, Run domain Beclin-1-interacting and cysteine-rich domain-containing protein in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human RUBCN (Arg710-Thr972).
靶标RUBCN, KIAA0226, Beclin-1 associated RUN domain containing protein, Rubicon, Baron, Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
纯化方式Purified by antigen affinity column.
Accession号Q92622
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN) is a ~108 kDa protein. Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation.

1. Sun, Q. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 19338-43. PMID: 20974968
2. Sun, Q. et al. (2011) The Journal of biological chemistry 286, 185-91. PMID: 21062745
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human RUBCN Polyclonal Antibody

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