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Anti-Human LYAR Polyclonal Antibody (ARO-A12920)

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概述
货号ARO-A12920
品牌ProteoGenix
描述
Anti-Human LYAR Polyclonal Antibody (ARO-A12920) is a rabbit polyclonal antibody detecting Cell growth-regulating nucleolar protein, LYAR in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human LYAR (Gly307-Lys379).
靶标Cell growth-regulating nucleolar protein, LYAR
纯化方式Purified by antigen affinity column.
Accession号Q9NX58
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Cell growth-regulating nucleolar protein (LYAR) is a ~43 kDa protein. Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs. Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression. In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA. Preferentially binds to a DNA motif containing 5'-GGTTAT-3'.

1. Miyazawa, N. et al. (2014) Genes to cells : devoted to molecular & cellular mechanisms 19, 273-86. PMID: 24495227
2. Ju, J. et al. (2014) Nucleic acids research 42, 9740-52. PMID: 25092918
3. Sun, Y. et al. (2017) Cell death and differentiation 24, 1645-1654. PMID: 28686580
4. Yang, C. et al. (2019) Journal of virology 93. PMID: 31413131
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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