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Anti-Human GNPDA1 Polyclonal Antibody (ARO-A13413)

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概述
货号ARO-A13413
品牌ProteoGenix
描述
Anti-Human GNPDA1 Polyclonal Antibody (ARO-A13413) is a rabbit polyclonal antibody detecting GNPDA1, GlcN6P deaminase 1, Glucosamine-6-phosphate deaminase 1, GNPI, GNPDA 1, Oscillin, KIAA0060, HLN, Glucosamine-6-phosphate isomerase 1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human GNPDA1 (Met1-Asp289).
靶标GNPDA1, GlcN6P deaminase 1, Glucosamine-6-phosphate deaminase 1, GNPI, GNPDA 1, Oscillin, KIAA0060, HLN, Glucosamine-6-phosphate isomerase 1
纯化方式Purified by antigen affinity column.
Accession号P46926
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Glucosamine-6-phosphate deaminase 1 (GNPDA1) is a ~32 kDa protein. Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. Seems to trigger calcium oscillations in mammalian eggs.

1. Alvarez-Añorve, LI. et al. (2011) Biochimica et biophysica acta 1814, 1846-53. PMID: 21807125
2. Oikari, S. et al. (2016) Glycobiology 26, 710-22. PMID: 26887390
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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