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Anti-Human SUZ12 Polyclonal Antibody (ARO-A11252)

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概述
货号ARO-A11252
品牌ProteoGenix
描述
Anti-Human SUZ12 Polyclonal Antibody (ARO-A11252) is a rabbit polyclonal antibody detecting SUZ12, Polycomb protein SUZ12, Joined to JAZF1 protein, CHET9, KIAA0160, ChET 9 protein, Suppressor of zeste 12 protein homolog, Chromatin precipitated E2F target 9 protein, JJAZ1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human SUZ12 (Lys587-Gly691).
靶标SUZ12, Polycomb protein SUZ12, Joined to JAZF1 protein, CHET9, KIAA0160, ChET 9 protein, Suppressor of zeste 12 protein homolog, Chromatin precipitated E2F target 9 protein, JJAZ1
纯化方式Purified by antigen affinity column.
Accession号Q15022
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Polycomb protein SUZ12 is a ~83 kDa protein. Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

1. Cao, R. et al. (2004) Molecular cell 15, 57-67. PMID: 15225548
2. Kirmizis, A. et al. (2004) Genes & development 18, 1592-605. PMID: 15231737
3. Pasini, D. et al. (2004) The EMBO journal 23, 4061-71. PMID: 15385962
4. Bracken, AP. et al. (2006) Genes & development 20, 1123-36. PMID: 16618801
5. Bracken, AP. et al. (2007) Genes & development 21, 525-30. PMID: 17344414
6. Sarma, K. et al. (2008) Molecular and cellular biology 28, 2718-31. PMID: 18285464
7. Imagawa, E. et al. (2017) Human mutation 38, 637-648. PMID: 28229514
8. Chen, S. et al. (2018) Molecular cell 69, 840-852.e5. PMID: 29499137
9. Chen, S. et al. (2020) Molecular cell 77, 1265-1278.e7. PMID: 31959557
10. Cao, R. et al. (2002) Science (New York, N.Y.) 298, 1039-43. PMID: 12351676
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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