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Anti-ARNT/HIF1-beta Polyclonal Antibody (ARO-A11316)

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概述
货号ARO-A11316
品牌ProteoGenix
描述
Anti-ARNT/HIF1-beta Polyclonal Antibody (ARO-A11316) is a rabbit polyclonal antibody detecting ARNT, Dioxin receptor, nuclear translocator, ARNT protein, bHLHe2, BHLHE2, Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 1-beta, HIF1-beta, Class E basic helix-loop-helix protein 2, HIF-1-beta in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human ARNT/HIF1-beta (Thr361-Val464).
靶标ARNT, Dioxin receptor, nuclear translocator, ARNT protein, bHLHe2, BHLHE2, Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 1-beta, HIF1-beta, Class E basic helix-loop-helix protein 2, HIF-1-beta
纯化方式Purified by antigen affinity column.
Accession号P27540
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Aryl hydrocarbon receptor nuclear translocator (ARNT/HIF1-beta) is a ~86 kDa protein. Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia.

1. Haidar, R. et al. (2021) Scientific reports 11, 18194. PMID: 34521881
2. Seok, SH. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 5431-5436. PMID: 28396409
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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