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Anti-Clostridioides difficile Toxin B/tcdB Polyclonal Antibody (ARO-A11393)

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概述
货号ARO-A11393
品牌ProteoGenix
描述
Anti-Clostridioides difficile Toxin B/tcdB Polyclonal Antibody (ARO-A11393) is a rabbit polyclonal antibody detecting Toxin B, 3.4.22.-, Glucosyltransferase TcdB, 2.4.1.-, tcdB, toxB, Clostridium difficile Toxin in ELISA, IHC, WB. Suitable for Clostridioides difficile (Peptoclostridium difficile).
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Clostridioides difficile (Peptoclostridium difficile)
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Clostridioides difficile Toxin B/tcdB (Gly1834-Glu2053).
靶标Toxin B, 3.4.22.-, Glucosyltransferase TcdB, 2.4.1.-, tcdB, toxB, Clostridium difficile Toxin
纯化方式Purified by antigen affinity column.
Accession号P18177
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Toxin B (tcdB) is a ~269 kDa protein. Precursor of a cytotoxin that targets and disrupts the colonic epithelium, inducing the host inflammatory and innate immune responses and resulting in diarrhea and pseudomembranous colitis. TcdB constitutes the main toxin that mediates the pathology of C.difficile infection, an opportunistic pathogen that colonizes the colon when the normal gut microbiome is disrupted. Compared to TcdA, TcdB is more virulent and more important for inducing the host inflammatory and innate immune responses. This form constitutes the precursor of the toxin: it enters into host cells and mediates autoprocessing to release the active toxin (Glucosyltransferase TcdB) into the host cytosol. Targets colonic epithelia by binding to the frizzled receptors FZD1, FZD2 and FZD7, and enters host cells via clathrin-mediated endocytosis.

1. Kuehne, SA. et al. (2010) Nature 467, 711-3. PMID: 20844489
2. Xu, H. et al. (2014) Nature 513, 237-41. PMID: 24919149
3. Lyras, D. et al. (2009) Nature 458, 1176-9. PMID: 19252482
4. Qa'Dan, M. et al. (2000) Infection and immunity 68, 2470-4. PMID: 10768933
5. Barth, H. et al. (2001) The Journal of biological chemistry 276, 10670-6. PMID: 11152463
6. Pfeifer, G. et al. (2003) The Journal of biological chemistry 278, 44535-41. PMID: 12941936
7. Reineke, J. et al. (2007) Nature 446, 415-9. PMID: 17334356
9. Tao, L. et al. (2016) Nature 538, 350-355. PMID: 27680706
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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