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Anti-CDC20 Polyclonal Antibody (ARO-A11435)

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概述
货号ARO-A11435
品牌ProteoGenix
描述
Anti-CDC20 Polyclonal Antibody (ARO-A11435) is a rabbit polyclonal antibody detecting Cell division cycle protein 20 homolog, p55CDC, CDC20 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human CDC20 (Gln218-Arg471).
靶标Cell division cycle protein 20 homolog, p55CDC, CDC20
纯化方式Purified by antigen affinity column.
Accession号Q12834
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Cell division cycle protein 20 homolog (CDC20) is a ~54 kDa protein. Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation. Recognizes and binds the destruction box (D box) on protein substrates. Involved in the metaphase/anaphase transition of cell cycle. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons.

1. Fang, G. et al. (1998) Molecular cell 2, 163-71. PMID: 9734353
2. Lin, Z. et al. (2015) Cell discovery 1, 15028-. PMID: 27030811
3. Choppara, S. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 998-1003. PMID: 29343641
4. Zhao, L. et al. (2020) Protein & cell 11, 921-927. PMID: 32666501
5. Kramer, ER. et al. (1998) Current biology : CB 8, 1207-10. PMID: 9811605
6. Fang, G. et al. (1998) Genes & development 12, 1871-83. PMID: 9637688
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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