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Anti-STIM1 Polyclonal Antibody (ARO-A11428)

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概述
货号ARO-A11428
品牌ProteoGenix
描述
Anti-STIM1 Polyclonal Antibody (ARO-A11428) is a rabbit polyclonal antibody detecting STIM1, Stromal interaction molecule 1, GOK in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human STIM1 (Ser28-Leu211).
靶标STIM1, Stromal interaction molecule 1, GOK
纯化方式Purified by antigen affinity column.
Accession号Q13586
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Stromal interaction molecule 1 (STIM1) is a ~77 kDa protein. Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels. Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry. Involved in enamel formation.

1. Roos, J. et al. (2005) The Journal of cell biology 169, 435-45. PMID: 15866891
2. Liou, J. et al. (2005) Current biology : CB 15, 1235-41. PMID: 16005298
3. Zhang, SL. et al. (2005) Nature 437, 902-5. PMID: 16208375
4. Spassova, MA. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 4040-5. PMID: 16537481
5. Peinelt, C. et al. (2006) Nature cell biology 8, 771-3. PMID: 16733527
6. Soboloff, J. et al. (2006) The Journal of biological chemistry 281, 20661-20665. PMID: 16766533
7. Mercer, JC. et al. (2006) The Journal of biological chemistry 281, 24979-90. PMID: 16807233
8. Stathopulos, PB. et al. (2008) Cell 135, 110-22. PMID: 18854159
9. Yuan, JP. et al. (2009) Nature cell biology 11, 337-43. PMID: 19182790
10. Park, CY. et al. (2009) Cell 136, 876-90. PMID: 19249086
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-STIM1 Polyclonal Antibody

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