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Anti-CYGB Polyclonal Antibody (ARO-A11500)

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概述
货号ARO-A11500
品牌ProteoGenix
描述
Anti-CYGB Polyclonal Antibody (ARO-A11500) is a rabbit polyclonal antibody detecting Histoglobin, CYGB, Stellate cell activation-associated protein, Cytoglobin, STAP, HGb in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human CYGB (Met1-Pro190).
靶标Histoglobin, CYGB, Stellate cell activation-associated protein, Cytoglobin, STAP, HGb
纯化方式Purified by antigen affinity column.
Accession号Q8WWM9
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Cytoglobin (CYGB) is a ~21 kDa protein. Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability. Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption. By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone. Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide. Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress.

1. Trent, JT. et al. (2002) The Journal of biological chemistry 277, 19538-45. PMID: 11893755
2. Asahina, K. et al. (2002) Biochimica et biophysica acta 1577, 471-5. PMID: 12359339
3. Sugimoto, H. et al. (2004) Journal of molecular biology 339, 873-85. PMID: 15165856
4. Halligan, KE. et al. (2009) The Journal of biological chemistry 284, 8539-47. PMID: 19147491
5. Gardner, AM. et al. (2010) The Journal of biological chemistry 285, 23850-7. PMID: 20511233
6. Liu, X. et al. (2017) Nature communications 8, 14807. PMID: 28393874
7. Amdahl, MB. et al. (2017) Biochemistry 56, 3993-4004. PMID: 28671819
8. Reeder, BJ. et al. (2018) Nitric oxide : biology and chemistry 72, 16-23. PMID: 29128400
9. Dat, NQ. et al. (2021) Hepatology (Baltimore, Md.) 73, 2527-2545. PMID: 33576020
10. Zweier, JL. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34930834
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-CYGB Polyclonal Antibody

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