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Anti-Human RAB3IP Polyclonal Antibody (ARO-A11856)

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概述
货号ARO-A11856
品牌ProteoGenix
描述
Anti-Human RAB3IP Polyclonal Antibody (ARO-A11856) is a rabbit polyclonal antibody detecting Rabin-3, Rab3A-interacting protein, Rab-3A-interacting protein, SSX2-interacting protein, RAB3IP, RABIN8 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human RAB3IP (Asp314-Leu476).
靶标Rabin-3, Rab3A-interacting protein, Rab-3A-interacting protein, SSX2-interacting protein, RAB3IP, RABIN8
纯化方式Purified by antigen affinity column.
Accession号Q96QF0
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Rab-3A-interacting protein (RAB3IP) is a ~53 kDa protein. Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.

1. Hattula, K. et al. (2002) Molecular biology of the cell 13, 3268-80. PMID: 12221131
2. Steger, M. et al. (2016) eLife 5. PMID: 26824392
3. Yoshimura, S. et al. (2010) The Journal of cell biology 191, 367-81. PMID: 20937701
4. Bryant, DM. et al. (2010) Nature cell biology 12, 1035-45. PMID: 20890297
5. Wang, J. et al. (2015) Journal of cell science 128, 1375-85. PMID: 25673879
6. Walia, V. et al. (2019) Developmental cell 50, 229-246.e7. PMID: 31204173
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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