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Anti-Human ZNF410 Polyclonal Antibody (ARO-A12061)

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概述
货号ARO-A12061
品牌ProteoGenix
描述
Anti-Human ZNF410 Polyclonal Antibody (ARO-A12061) is a rabbit polyclonal antibody detecting ZNF410, APA1, Another partner for ARF 1, Zinc finger protein 410, Zinc finger protein APA-1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human ZNF410 (Arg76-Ser191).
靶标ZNF410, APA1, Another partner for ARF 1, Zinc finger protein 410, Zinc finger protein APA-1
纯化方式Purified by antigen affinity column.
Accession号Q86VK4
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Zinc finger protein 410 (ZNF410) is a ~52 kDa protein. Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells. Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells. May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence. May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose. However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4.

1. Lan, X. et al. (2021) Molecular cell 81, 239-254.e8. PMID: 33301730
2. Vinjamur, DS. et al. (2021) Nature genetics 53, 719-728. PMID: 33859416
3. Benanti, JA. et al. (2002) Molecular and cellular biology 22, 7385-97. PMID: 12370286
4. Chen, Y. et al. (2018) Journal of cellular physiology 234, 606-618. PMID: 30078215
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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