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Anti-Human RFWD3 Polyclonal Antibody (ARO-A12164)

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概述
货号ARO-A12164
品牌ProteoGenix
描述
Anti-Human RFWD3 Polyclonal Antibody (ARO-A12164) is a rabbit polyclonal antibody detecting RING finger and WD repeat domain-containing protein 3, RNF201, E3 ubiquitin-protein ligase RFWD3, RING finger protein 201, RFWD3 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human RFWD3 (Gly430-Glu774).
靶标RING finger and WD repeat domain-containing protein 3, RNF201, E3 ubiquitin-protein ligase RFWD3, RING finger protein 201, RFWD3
纯化方式Purified by antigen affinity column.
Accession号Q6PCD5
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

E3 ubiquitin-protein ligase RFWD3 is a ~85 kDa protein. E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair. Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination. Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome.

1. Gong, Z. et al. (2011) The Journal of biological chemistry 286, 22308-13. PMID: 21504906
2. Liu, S. et al. (2011) The Journal of biological chemistry 286, 22314-22. PMID: 21558276
3. Elia, AE. et al. (2015) Molecular cell 60, 280-93. PMID: 26474068
4. Feeney, L. et al. (2017) Molecular cell 66, 610-621.e4. PMID: 28575657
5. Inano, S. et al. (2017) Molecular cell 66, 622-634.e8. PMID: 28575658
6. Gallina, I. et al. (2021) Molecular cell 81, 442-458.e9. PMID: 33321094
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human RFWD3 Polyclonal Antibody

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