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Anti-Human SENP3 Polyclonal Antibody (ARO-A12160)

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概述
货号ARO-A12160
品牌ProteoGenix
描述
Anti-Human SENP3 Polyclonal Antibody (ARO-A12160) is a rabbit polyclonal antibody detecting Sentrin-specific protease 3, Sentrin/SUMO-specific protease SENP3, SENP3, SUSP3, SUMO-1-specific protease 3, SSP3 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human SENP3 (Glu311-Val574).
靶标Sentrin-specific protease 3, Sentrin/SUMO-specific protease SENP3, SENP3, SUSP3, SUMO-1-specific protease 3, SSP3
纯化方式Purified by antigen affinity column.
Accession号Q9H4L4
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Sentrin-specific protease 3 (SENP3) is a ~65 kDa protein. Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1.

1. Gong, L. et al. (2006) The Journal of biological chemistry 281, 15869-77. PMID: 16608850
2. Gao, SS. et al. (2020) Science advances 6, eaba7822. PMID: 32832608
3. Zhang, T. et al. (2022) Nature communications 13, 5133. PMID: 36050397
4. Grégoire, S. et al. (2005) Molecular and cellular biology 25, 2273-87. PMID: 15743823
5. Klein, UR. et al. (2009) Molecular biology of the cell 20, 410-8. PMID: 18946085
6. Huang, C. et al. (2009) The EMBO journal 28, 2748-62. PMID: 19680224
7. Yun, C. et al. (2008) The Journal of cell biology 183, 589-95. PMID: 19015314
8. Haindl, M. et al. (2008) EMBO reports 9, 273-9. PMID: 18259216
9. Fanis, P. et al. (2012) Molecular & cellular proteomics : MCP 11, 1263-73. PMID: 22872859
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human SENP3 Polyclonal Antibody

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