

| 货号 | ARO-A12311 |
|---|---|
| 品牌 | ProteoGenix |
| 描述 |
Anti-Human OS9 Polyclonal Antibody (ARO-A12311) is a rabbit polyclonal antibody detecting Protein OS-9, OS9, Amplified in osteosarcoma 9 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
| 种属反应性 | Human |
| 应用 | ELISA, IHC, WB |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal |
| 同种型 | IgG |
| 免疫原 | E. coli - derived recombinant Human OS9 (Asn32-Gln251). |
| 靶标 | Protein OS-9, OS9, Amplified in osteosarcoma 9 |
| 纯化方式 | Purified by antigen affinity column. |
| Accession号 | Q13438 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Protein OS-9 (OS9) is a ~75 kDa protein. Lectin component of the HRD1 complex, which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). Specifically recognizes and binds improperly folded glycoproteins as well as hyperglycosylated proteins, retain them in the ER, and transfers them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 as well as hyperglycosylated HSP90B1. 1. Christianson, JC. et al. (2008) Nature cell biology 10, 272-82. PMID: 18264092 2. Bernasconi, R. et al. (2008) The Journal of biological chemistry 283, 16446-54. PMID: 18417469 3. Alcock, F. et al. (2009) Journal of molecular biology 385, 1032-42. PMID: 19084021 4. Hosokawa, N. et al. (2009) The Journal of biological chemistry 284, 17061-17068. PMID: 19346256 5. Satoh, T. et al. (2010) Molecular cell 40, 905-16. PMID: 21172656 6. Dersh, D. et al. (2014) Molecular biology of the cell 25, 2220-34. PMID: 24899641 |
| Note | For research use only. |

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