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Anti-Human HEXIM1 Polyclonal Antibody (ARO-A12363)

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概述
货号ARO-A12363
品牌ProteoGenix
描述
Anti-Human HEXIM1 Polyclonal Antibody (ARO-A12363) is a rabbit polyclonal antibody detecting Protein HEXIM1, Cardiac lineage protein 1, HIS1, Menage a quatre protein 1, EDG1, Estrogen down-regulated gene 1 protein, HEXIM1, Hexamethylene bis-acetamide-inducible protein 1, MAQ1, CLP1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human HEXIM1 (Asp258-Asp359).
靶标Protein HEXIM1, Cardiac lineage protein 1, HIS1, Menage a quatre protein 1, EDG1, Estrogen down-regulated gene 1 protein, HEXIM1, Hexamethylene bis-acetamide-inducible protein 1, MAQ1, CLP1
纯化方式Purified by antigen affinity column.
Accession号O94992
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Protein HEXIM1 is a ~40 kDa protein. Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.

1. Yik, JH. et al. (2003) Molecular cell 12, 971-82. PMID: 14580347
2. Michels, AA. et al. (2004) The EMBO journal 23, 2608-19. PMID: 15201869
3. Yik, JH. et al. (2005) The Journal of biological chemistry 280, 16368-76. PMID: 15713661
4. Michels, AA. et al. (2003) Molecular and cellular biology 23, 4859-69. PMID: 12832472
5. Wittmann, BM. et al. (2005) Oncogene 24, 5576-88. PMID: 15940264
6. Shimizu, N. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8555-60. PMID: 15941832
7. Kohoutek, J. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 17349-54. PMID: 17088550
8. Morchikh, M. et al. (2017) Molecular cell 67, 387-399.e5. PMID: 28712728
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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