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Anti-Human ING4 Polyclonal Antibody (ARO-A12432)

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概述
货号ARO-A12432
品牌ProteoGenix
描述
Anti-Human ING4 Polyclonal Antibody (ARO-A12432) is a rabbit polyclonal antibody detecting ING4, Inhibitor of growth protein 4, p29ING4 in ELISA, IHC, WB. Suitable for Human, Mouse, Bos taurus, Chicken.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Bos taurus, Chicken
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human ING4 (Met1-Lys127).
靶标ING4, Inhibitor of growth protein 4, p29ING4
纯化方式Purified by antigen affinity column.
Accession号Q9UNL4
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Inhibitor of growth protein 4 (ING4) is a ~28 kDa protein. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC.

1. Doyon, Y. et al. (2006) Molecular cell 21, 51-64. PMID: 16387653
2. Zhang, X. et al. (2004) FEBS letters 570, 7-12. PMID: 15251430
3. Kim, S. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 16251-6. PMID: 15528276
4. Garkavtsev, I. et al. (2004) Nature 428, 328-32. PMID: 15029197
5. Ozer, A. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 7481-6. PMID: 15897452
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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