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Anti-Human IST1 Polyclonal Antibody (ARO-A12524)

概述
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参考文献

概述

货号	ARO-A12524
品牌	ProteoGenix
描述	Anti-Human IST1 Polyclonal Antibody (ARO-A12524) is a rabbit polyclonal antibody detecting Putative MAPK-activating protein PM28, IST1, IST1 homolog, KIAA0174, hIST1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bos taurus, Pongo abelii. Highlights Affinity Purified — Minimal background and high purity for reliable results. Multi-Application — Validated across multiple applications. Multi-Species — Cross-reactive for translational research.
种属反应性	Human, Mouse, Rat, Bos taurus, Pongo abelii
应用	ELISA, IHC, WB
宿主	Rabbit
克隆类型	Polyclonal
同种型	IgG
免疫原	E. coli - derived recombinant Human IST1 (Met1-Glu186).
靶标	Putative MAPK-activating protein PM28, IST1, IST1 homolog, KIAA0174, hIST1
纯化方式	Purified by antigen affinity column.
Accession号	P53990
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	IST1 homolog is a ~39 kDa protein. ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. 1. Bajorek, M. et al. (2009) Molecular biology of the cell 20, 1360-73. PMID: 19129479 2. Vietri, M. et al. (2015) Nature 522, 231-5. PMID: 26040712 3. Gu, M. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2166-E2175. PMID: 28242692 4. Agromayor, M. et al. (2009) Molecular biology of the cell 20, 1374-87. PMID: 19129480 5. Allison, R. et al. (2013) The Journal of cell biology 202, 527-43. PMID: 23897888
Note	For research use only.

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参考文献

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

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浓度

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体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

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V₁ (起始体积)

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工作液

C₂ (终浓度)

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V₂ (终体积)

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Anti-Human IST1 Polyclonal Antibody

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