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Anti-Human PHLPP1 Polyclonal Antibody (ARO-A12518)

概述
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参考文献

概述

货号	ARO-A12518
品牌	ProteoGenix
描述	Anti-Human PHLPP1 Polyclonal Antibody (ARO-A12518) is a rabbit polyclonal antibody detecting KIAA0606, Pleckstrin homology domain-containing family E member 1, hSCOP, PHLPP, SCOP, PHLPP1, PH domain leucine-rich repeat-containing protein phosphatase 1, PLEKHE1, Suprachiasmatic nucleus circadian oscillatory protein, PH domain-containing family E member 1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat. Highlights Affinity Purified — Minimal background and high purity for reliable results. Multi-Application — Validated across multiple applications. Multi-Species — Cross-reactive for translational research.
种属反应性	Human, Mouse, Rat
应用	ELISA, IHC, WB
宿主	Rabbit
克隆类型	Polyclonal
同种型	IgG
免疫原	E. coli - derived recombinant Human PHLPP1 (Ser1168-Thr1425).
靶标	KIAA0606, Pleckstrin homology domain-containing family E member 1, hSCOP, PHLPP, SCOP, PHLPP1, PH domain leucine-rich repeat-containing protein phosphatase 1, PLEKHE1, Suprachiasmatic nucleus circadian oscillatory protein, PH domain-containing family E member 1
纯化方式	Purified by antigen affinity column.
Accession号	O60346
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	PH domain leucine-rich repeat-containing protein phosphatase 1 (PHLPP1) is a ~184 kDa protein. Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA. Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. 1. Gao, T. et al. (2005) Molecular cell 18, 13-24. PMID: 15808505 2. Brognard, J. et al. (2007) Molecular cell 25, 917-31. PMID: 17386267 3. Gao, T. et al. (2008) The Journal of biological chemistry 283, 6300-11. PMID: 18162466 4. Qiao, M. et al. (2010) Molecular cell 38, 512-23. PMID: 20513427 5. Liu, J. et al. (2011) Molecular and cellular biology 31, 4917-27. PMID: 21986499 6. Liu, J. et al. (2009) Oncogene 28, 994-1004. PMID: 19079341 7. Li, X. et al. (2014) Gastroenterology 146, 1301-12.e1-10. PMID: 24530606
Note	For research use only.

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参考文献

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

=

浓度

×

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

×

V₁ (起始体积)

=

工作液

C₂ (终浓度)

×

V₂ (终体积)

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Anti-Human PHLPP1 Polyclonal Antibody

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