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Anti-Human GBP1 Polyclonal Antibody (ARO-A12465)

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概述
货号ARO-A12465
品牌ProteoGenix
描述
Anti-Human GBP1 Polyclonal Antibody (ARO-A12465) is a rabbit polyclonal antibody detecting Guanine nucleotide-binding protein 1, HuGBP-1, GBP-1, Interferon-induced guanylate-binding protein 1, GBP1, GTP-binding protein 1, Guanylate-binding protein 1 in ELISA, IHC, WB. Suitable for Human, Chlorocebus aethiops, Pongo abelii.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Chlorocebus aethiops, Pongo abelii
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human GBP1 (Met1-Ser592).
靶标Guanine nucleotide-binding protein 1, HuGBP-1, GBP-1, Interferon-induced guanylate-binding protein 1, GBP1, GTP-binding protein 1, Guanylate-binding protein 1
纯化方式Purified by antigen affinity column.
Accession号P32455
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Guanylate-binding protein 1 (GBP1) is a ~67 kDa protein. Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Hydrolyzes GTP to GMP in two consecutive cleavage reactions: GTP is first hydrolyzed to GDP and then to GMP in a processive manner. Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and promotes both inflammasome assembly and autophagy. Acts as a positive regulator of inflammasome assembly by facilitating the detection of inflammasome ligands from pathogens. Involved in the lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol.

1. Ghosh, A. et al. (2006) Nature 440, 101-4. PMID: 16511497
2. Nordmann, A. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 1290-300. PMID: 22106366
3. Li, P. et al. (2017) Nature 551, 378-383. PMID: 29144452
4. Fisch, D. et al. (2019) The EMBO journal 38, e100926. PMID: 31268602
5. Kutsch, M. et al. (2020) The EMBO journal 39, e104926. PMID: 32510692
6. Santos, JC. et al. (2020) Nature communications 11, 3276. PMID: 32581219
7. Fisch, D. et al. (2023) Science (New York, N.Y.) 382, eadg2253. PMID: 37797010
8. Schwemmle, M. et al. (1994) The Journal of biological chemistry 269, 11299-305. PMID: 7512561
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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