Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) is a ~35 kDa protein. Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1.
1. Abraham, D. et al. (2000) The Journal of biological chemistry 275, 22300-4. PMID: 10801873
2. Losman, JA. et al. (2003) The Journal of biological chemistry 278, 4800-5. PMID: 12473674
3. Li, HH. et al. (2007) The EMBO journal 26, 402-11. PMID: 17245430
4. Watkins, GR. et al. (2012) The Journal of biological chemistry 287, 24207-15. PMID: 22613722
5. Zheng, H. et al. (2020) Science (New York, N.Y.) 370. PMID: 33243860
