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Anti-Human TUT4 Polyclonal Antibody (ARO-A12520)

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概述
货号ARO-A12520
品牌ProteoGenix
描述
Anti-Human TUT4 Polyclonal Antibody (ARO-A12520) is a rabbit polyclonal antibody detecting TUTase 4, KIAA0191, TUT4, ZCCHC11, Terminal uridylyltransferase 4, Zinc finger CCHC domain-containing protein 11 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human TUT4 (Glu246-Asp370).
靶标TUTase 4, KIAA0191, TUT4, ZCCHC11, Terminal uridylyltransferase 4, Zinc finger CCHC domain-containing protein 11
纯化方式Purified by antigen affinity column.
Accession号Q5TAX3
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Terminal uridylyltransferase 4 (TUT4) is a ~185 kDa protein. Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth. Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms.

1. Lim, J. et al. (2014) Cell 159, 1365-76. PMID: 25480299
2. Yamashita, S. et al. (2019) Nature communications 10, 1960. PMID: 31036859
3. Kim, B. et al. (2015) The EMBO journal 34, 1801-15. PMID: 25979828
4. Heo, I. et al. (2009) Cell 138, 696-708. PMID: 19703396
5. Minoda, Y. et al. (2006) Biochemical and biophysical research communications 344, 1023-30. PMID: 16643855
6. Mullen, TE. et al. (2008) Genes & development 22, 50-65. PMID: 18172165
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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