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Anti-Human TNFAIP8L2 Polyclonal Antibody (ARO-A12542)

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概述
货号ARO-A12542
品牌ProteoGenix
描述
Anti-Human TNFAIP8L2 Polyclonal Antibody (ARO-A12542) is a rabbit polyclonal antibody detecting TNF alpha-induced protein 8-like protein 2, Tumor necrosis factor alpha-induced protein 8-like protein 2, TNFAIP8-like protein 2, Inflammation factor protein 20, TIPE2, TNFAIP8L2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bos taurus, Callithrix jacchus, Oryctolagus cuniculus, Otolemur garnettii, Papio anubis, Rhinolophus ferrumequinum.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat, Bos taurus, Callithrix jacchus, Oryctolagus cuniculus, Otolemur garnettii, Papio anubis, Rhinolophus ferrumequinum
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human TNFAIP8L2 (Met1-Leu184).
靶标TNF alpha-induced protein 8-like protein 2, Tumor necrosis factor alpha-induced protein 8-like protein 2, TNFAIP8-like protein 2, Inflammation factor protein 20, TIPE2, TNFAIP8L2
纯化方式Purified by antigen affinity column.
Accession号Q6P589
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Tumor necrosis factor alpha-induced protein 8-like protein 2 (TNFAIP8L2) is a ~20 kDa protein. Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression. Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness. Also inhibits autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex. Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity.

1. Suo, LG. et al. (2016) Molecular immunology 73, 46-52. PMID: 27043859
2. Lou, Y. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 204, 2122-2132. PMID: 32188758
3. Li, W. et al. (2021) Autophagy 17, 1410-1425. PMID: 32460619
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human TNFAIP8L2 Polyclonal Antibody

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