Anti-Human ELAVL1 Polyclonal Antibody (ARO-A12630) is a rabbit polyclonal antibody detecting ELAV-like protein 1, HuR, ELAVL1, Hu-antigen R, HUR in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Xenopus laevis, Xenopus tropicalis.
Highlights
Affinity Purified — Minimal background and high purity for reliable results.
Multi-Application — Validated across multiple applications.
Multi-Species — Cross-reactive for translational research.
种属反应性
Human, Mouse, Rat, Xenopus laevis, Xenopus tropicalis
应用
ELISA, IHC, WB
宿主
Rabbit
同种型
IgG
克隆类型
Polyclonal
免疫原
E. coli - derived recombinant Human ELAVL1 (Gly18-Gln198).
靶标
ELAV-like protein 1, HuR, ELAVL1, Hu-antigen R, HUR
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
ELAV-like protein 1 (ELAVL1) is a ~36 kDa protein. RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation. Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs.
1. Tran, H. et al. (2003) Molecular and cellular biology 23, 7177-88. PMID: 14517288
2. Doller, A. et al. (2008) Molecular and cellular biology 28, 2608-25. PMID: 18285462
