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Anti-Human NEU3/Sialidase-3 Polyclonal Antibody (ARO-A12672)

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概述
货号ARO-A12672
品牌ProteoGenix
描述
Anti-Human NEU3/Sialidase-3 Polyclonal Antibody (ARO-A12672) is a rabbit polyclonal antibody detecting N-acetyl-alpha-neuraminidase 3, NEU3, Sialidase-3, Ganglioside sialidasedis, Membrane sialidase in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human NEU3/Sialidase-3 (Met1-Asn428).
靶标N-acetyl-alpha-neuraminidase 3, NEU3, Sialidase-3, Ganglioside sialidasedis, Membrane sialidase
纯化方式Purified by antigen affinity column.
Accession号Q9UQ49
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Sialidase-3 (NEU3) is a ~48 kDa protein. Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes.

1. Wada, T. et al. (1999) Biochemical and biophysical research communications 261, 21-7. PMID: 10405317
2. Monti, E. et al. (2000) The Biochemical journal 349, 343-51. PMID: 10861246
3. Wang, Y. et al. (2001) European journal of biochemistry 268, 2201-8. PMID: 11298736
4. Wang, Y. et al. (2002) The Journal of biological chemistry 277, 26252-9. PMID: 12011038
5. Yamaguchi, K. et al. (2005) The Biochemical journal 390, 85-93. PMID: 15847605
6. Albohy, A. et al. (2010) Glycobiology 20, 1127-38. PMID: 20511247
7. Rodriguez-Walker, M. et al. (2017) Scientific reports 7, 4167. PMID: 28646141
8. Wada, T. et al. (2007) Oncogene 26, 2483-90. PMID: 17334392
9. Mozzi, A. et al. (2015) Glycobiology 25, 855-68. PMID: 25922362
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human NEU3/Sialidase-3 Polyclonal Antibody

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