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Anti-Human RB1CC1 Polyclonal Antibody (ARO-A12649)

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概述
货号ARO-A12649
品牌ProteoGenix
描述
Anti-Human RB1CC1 Polyclonal Antibody (ARO-A12649) is a rabbit polyclonal antibody detecting FAK family kinase-interacting protein of 200 kDa, RB1CC1, FIP200, RBICC, RB1-inducible coiled-coil protein 1, KIAA0203 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human RB1CC1 (Glu1447-Val1594).
靶标FAK family kinase-interacting protein of 200 kDa, RB1CC1, FIP200, RBICC, RB1-inducible coiled-coil protein 1, KIAA0203
纯化方式Purified by antigen affinity column.
Accession号Q8TDY2
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

RB1-inducible coiled-coil protein 1 (RB1CC1) is a ~183 kDa protein. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways.

1. Morselli, E. et al. (2011) Cell cycle (Georgetown, Tex.) 10, 2763-9. PMID: 21775823
2. Nishimura, T. et al. (2013) EMBO reports 14, 284-91. PMID: 23392225
3. Ueda, H. et al. (2000) The Journal of cell biology 149, 423-30. PMID: 10769033
4. Abbi, S. et al. (2002) Molecular biology of the cell 13, 3178-91. PMID: 12221124
5. Chano, T. et al. (2002) Gene 291, 29-34. PMID: 12095676
6. Kontani, K. et al. (2003) International journal of molecular medicine 12, 767-9. PMID: 14533007
7. Chano, T. et al. (2002) The American journal of pathology 161, 359-64. PMID: 12163359
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human RB1CC1 Polyclonal Antibody

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