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Anti-Clostridium novyi Toxin A/tcdA Polyclonal Antibody (ARO-A12681)

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概述
货号ARO-A12681
品牌ProteoGenix
描述
Anti-Clostridium novyi Toxin A/tcdA Polyclonal Antibody (ARO-A12681) is a rabbit polyclonal antibody detecting Toxin A, 3.4.22.-, N-acetylglucosaminyltransferase TcdA, 2.4.1.-, tcdA, toxA in ELISA, IHC, WB. Suitable for Clostridium novyi.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Clostridium novyi
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Clostridium novyi Toxin A/tcdA (Met1-Glu551).
靶标Toxin A, 3.4.22.-, N-acetylglucosaminyltransferase TcdA, 2.4.1.-, tcdA, toxA
纯化方式Purified by antigen affinity column.
Accession号Q46149
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Toxin A (tcdA) is a ~250 kDa protein. Precursor of a cytotoxin, which enters into host cells and mediates autoprocessing to release the active toxin (N-acetylglucosaminyltransferase TcdA) into the host cytosol. Once entered into host cells, acidification in the endosome promotes the membrane insertion of the translocation region and formation of a pore, leading to translocation of the GT44 and peptidase C80 domains across the endosomal membrane. This activates the peptidase C80 domain and autocatalytic processing, releasing the N-terminal part (N-acetylglucosaminyltransferase TcdA), which constitutes the active part of the toxin, in the cytosol.

1. Reineke, J. et al. (2007) Nature 446, 415-9. PMID: 17334356
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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