E. coli - derived recombinant Human SKP1 (Met1-Lys163).
靶标
p19A, Organ of Corti protein 2, EMC19, SKP1, Organ of Corti protein II, OCP2, OCP-2, RNA polymerase II elongation factor-like protein, Cyclin-A/CDK2-associated protein p19, OCP-II, p19skp1, TCEB1L, S-phase kinase-associated protein 1, SIII, Transcription elongation factor B polypeptide 1-like, SKP1A
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
S-phase kinase-associated protein 1 (SKP1) is a ~18 kDa protein. Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA.
1. Man, X. et al. (2015) European journal of cell biology 94, 162-72. PMID: 25704143
