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Anti-WWTR1 Polyclonal Antibody (ARO-A13652)

概述
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参考文献

概述

货号	ARO-A13652
品牌	ProteoGenix
描述	Anti-WWTR1 Polyclonal Antibody (ARO-A13652) is a rabbit polyclonal antibody detecting Transcriptional coactivator with PDZ-binding motif, TAZ, WW domain-containing transcription regulator protein 1, WWTR1 in ELISA, IHC, WB. Suitable for Human, Mouse, Dog. Highlights Affinity Purified — Minimal background and high purity for reliable results. Multi-Application — Validated across multiple applications. Multi-Species — Cross-reactive for translational research.
种属反应性	Human, Mouse, Dog
应用	ELISA, IHC, WB
宿主	Rabbit
同种型	IgG
克隆类型	Polyclonal
免疫原	E. coli - derived recombinant Human WWTR1 (Met1-Leu400).
靶标	Transcriptional coactivator with PDZ-binding motif, TAZ, WW domain-containing transcription regulator protein 1, WWTR1
纯化方式	Purified by antigen affinity column.
Accession号	Q9GZV5
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	WW domain-containing transcription regulator protein 1 (WWTR1) is a ~44 kDa protein. Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. 1. Kanai, F. et al. (2000) The EMBO journal 19, 6778-91. PMID: 11118213 2. Lei, QY. et al. (2008) Molecular and cellular biology 28, 2426-36. PMID: 18227151 3. Lucci, V. et al. (2013) Gene 529, 300-6. PMID: 23911299 4. Di Palma, T. et al. (2009) Experimental cell research 315, 162-75. PMID: 19010321 5. Varelas, X. et al. (2008) Nature cell biology 10, 837-48. PMID: 18568018
Note	For research use only.

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参考文献

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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质量

=

浓度

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体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

×

V₁ (起始体积)

=

工作液

C₂ (终浓度)

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V₂ (终体积)

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Anti-WWTR1 Polyclonal Antibody

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