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Anti-CPEB1 Polyclonal Antibody (ARO-A13656)

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概述
货号ARO-A13656
品牌ProteoGenix
描述
Anti-CPEB1 Polyclonal Antibody (ARO-A13656) is a rabbit polyclonal antibody detecting CPEB, hCPEB-1, Cytoplasmic polyadenylation element-binding protein 1, CPE-binding protein 1, CPEB1, h-CPEB, CPE-BP1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Pongo abelii, Xenopus laevis.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat, Pongo abelii, Xenopus laevis
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human CPEB1 (Cys311-Lys561).
靶标CPEB, hCPEB-1, Cytoplasmic polyadenylation element-binding protein 1, CPE-binding protein 1, CPEB1, h-CPEB, CPE-BP1
纯化方式Purified by antigen affinity column.
Accession号Q9BZB8
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Cytoplasmic polyadenylation element-binding protein 1 (CPEB1) is a ~62 kDa protein. Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses.

1. Afroz, T. et al. (2014) Genes & development 28, 1498-514. PMID: 24990967
2. Giangarrà, V. et al. (2015) PloS one 10, e0138794. PMID: 26398195
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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