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Anti-TRADD Polyclonal Antibody (ARO-A13788)

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概述
货号ARO-A13788
品牌ProteoGenix
描述
Anti-TRADD Polyclonal Antibody (ARO-A13788) is a rabbit polyclonal antibody detecting TRADD, TNFR1-associated DEATH domain protein, Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFRSF1A-associated via death domain in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human TRADD (Met61-Leu297).
靶标TRADD, TNFR1-associated DEATH domain protein, Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFRSF1A-associated via death domain
纯化方式Purified by antigen affinity column.
Accession号Q15628
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) is a ~34 kDa protein. Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A.

1. Li, S. et al. (2013) Nature 501, 242-6. PMID: 23955153
2. Hsu, H. et al. (1995) Cell 81, 495-504. PMID: 7758105
3. Hsu, H. et al. (1996) Immunity 4, 387-96. PMID: 8612133
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-TRADD Polyclonal Antibody

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