Anti-TDP43 Polyclonal Antibody (ARO-A13831) is a rabbit polyclonal antibody detecting TAR DNA-binding protein 43, TARDBP, TDP-43, TDP43 in ELISA, IHC, WB. Suitable for Human, Mouse, Chicken, Pongo abelii, Xenopus tropicalis.
Highlights
Affinity Purified — Minimal background and high purity for reliable results.
Multi-Application — Validated across multiple applications.
Multi-Species — Cross-reactive for translational research.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
TAR DNA-binding protein 43 (TARDBP/TDP43) is a ~44 kDa protein. RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening.
1. Bhardwaj, A. et al. (2013) Nucleic acids research 41, 5062-74. PMID: 23519609
