Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
DNA repair protein RAD51 homolog 1 is a ~36 kDa protein. Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR.
1. Sigurdsson, S. et al. (2002) The Journal of biological chemistry 277, 42790-4. PMID: 12205100
2. Park, JY. et al. (2008) Nucleic acids research 36, 3226-34. PMID: 18417535
3. Islam, MN. et al. (2010) Molecular and cellular biology 30, 2460-72. PMID: 20231364
4. Schwendener, S. et al. (2010) The Journal of biological chemistry 285, 15739-45. PMID: 20348101
5. Yata, K. et al. (2012) Molecular cell 45, 371-83. PMID: 22325354
6. Wan, L. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 10646-51. PMID: 23509288
7. Yuan, J. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 10640-5. PMID: 23754376
8. Ameziane, N. et al. (2015) Nature communications 6, 8829. PMID: 26681308
9. Inano, S. et al. (2017) Molecular cell 66, 622-634.e8. PMID: 28575658
10. Brannvoll, A. et al. (2020) Cell reports 32, 107849. PMID: 32640219
