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Anti-GM130/GOLGA2 Polyclonal Antibody (ARO-A13844)

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概述
货号ARO-A13844
品牌ProteoGenix
描述
Anti-GM130/GOLGA2 Polyclonal Antibody (ARO-A13844) is a rabbit polyclonal antibody detecting 130 kDa cis-Golgi matrix protein, GM130, GM130 autoantigen, Golgin-95, Golgin subfamily A member 2, GOLGA2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human GM130/GOLGA2 (Ala361-Ala678).
靶标130 kDa cis-Golgi matrix protein, GM130, GM130 autoantigen, Golgin-95, Golgin subfamily A member 2, GOLGA2
纯化方式Purified by antigen affinity column.
Accession号Q08379
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Golgin subfamily A member 2 (GM130/GOLGA2) is a ~113 kDa protein. Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis. Also plays a key role in spindle pole assembly and centrosome organization.

1. Puthenveedu, MA. et al. (2006) Nature cell biology 8, 238-48. PMID: 16489344
2. Wei, JH. et al. (2015) Cell 162, 287-299. PMID: 26165940
3. Rivero, S. et al. (2009) The EMBO journal 28, 1016-28. PMID: 19242490
4. Kodani, A. et al. (2008) Molecular biology of the cell 19, 745-53. PMID: 18045989
5. Kodani, A. et al. (2009) Molecular biology of the cell 20, 1192-200. PMID: 19109421
6. Marra, P. et al. (2007) Molecular biology of the cell 18, 1595-608. PMID: 17314401
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-GM130/GOLGA2 Polyclonal Antibody

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