Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Ras-related protein Rab-11A (RAB11A) is a ~24 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB11A regulates endocytic recycling. Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC). Acts as a major regulator of membrane delivery during cytokinesis.
1. Wilson, GM. et al. (2005) Molecular biology of the cell 16, 849-60. PMID: 15601896
2. Lock, JG. et al. (2005) Molecular biology of the cell 16, 1744-55. PMID: 15689490
3. Swiatecka-Urban, A. et al. (2007) The Journal of biological chemistry 282, 23725-36. PMID: 17462998
4. Chu, BB. et al. (2009) The Journal of biological chemistry 284, 22481-22490. PMID: 19542231
5. Horgan, CP. et al. (2010) Journal of cell science 123, 181-91. PMID: 20026645
