Ras-related protein Rab-11A (RAB11A) is a ~24 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB11A regulates endocytic recycling. Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC). Acts as a major regulator of membrane delivery during cytokinesis. 1. Wilson, GM. et al. (2005) Molecular biology of the cell 16, 849-60. PMID: 156018962. Lock, JG. et al. (2005) Molecular biology of the cell 16, 1744-55. PMID: 156894903. Swiatecka-Urban, A. et al. (2007) The Journal of biological chemistry 282, 23725-36. PMID: 174629984. Chu, BB. et al. (2009) The Journal of biological chemistry 284, 22481-22490. PMID: 195422315. Horgan, CP. et al. (2010) Journal of cell science 123, 181-91. PMID: 200266456. Bryant, DM. et al. (2010) Nature cell biology 12, 1035-45. PMID: 208902977. Roland, JT. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2789-94. PMID: 212826568. Lall, P. et al. (2015) The Journal of biological chemistry 290, 18817-32. PMID: 260324129. Wang, J. et al. (2015) Journal of cell science 128, 1375-85. PMID: 2567387910. Walia, V. et al. (2019) Developmental cell 50, 229-246.e7. PMID: 31204173 | 
